A US biotech firm, Cytori Therapeutics, has reported results from a pre-clinical study suggesting adipose-derived regenerative cells (ADRCs) may reverse the effects of periodontal disease.
The data were reported today at the 95th Annual Meeting of the American Academy of Periodontology in Boston.
 |
As part of the study design, 20 immuno-deficient rats were treated for four critical defects in each. One of the defects was treated with uncultured human ADRCs and a second with cultured human adipose-derived stem cells (ADSC's), both in Platelet Rich Plasma (PRP). A third was treated with PRP alone and a fourth with no treatment. The study's results showed that at six weeks post-treatment the defects treated with the uncultured ADRCs and with the cultured ADSCs showed a statistically significant (p<0.001) improvement in healing of the alveolar bone compared to the two controls. Furthermore, uncultured ADRC and cultured ADSC treatment significantly decreased the gingival invasion of the defect when compared to no treatment (p<0.001) and PRP alone (p<0.05). |
